Dr Luke Hughes

Associate Professor

Department: Sport, Exercise and Rehabilitation

Dr Luke Hughes is an exercise physiologist specialising in clinical exercise and aerospace physiology. He obtained his PhD in clinical exercise physiology in 2019, which developing a novel exercise rehabilitation technique termed “blood flow restriction exercise”.

Research Themes and Scholarly Interests:

My research focusses on understanding the physiological mechanisms of health and deconditioning, and development of novel interventions to optimise human health, performance and rehabilitation in high-performance (e.g. professional/elite sport, human spaceflight) and clinical medicine populations. Within clinical medicine, my work focusses on the use of ‘blood flow restriction exercise’, a novel low-intensity exercise intervention, to improve health in deconditioned populations and improve post-surgical outcomes in several medical conditions and diseases. I have implemented this technique in the UK National Health Service, initially through clinical trials and now as part of standard rehabilitation. I am now working to develop blood flow restriction exercise as a countermeasure to improve astronaut health and mitigate deconditioning during spaceflight, and optimise post-flight rehabilitation outcomes.

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Key Publications

Please visit the Pure Research Information Portal for further information
Acute hypoalgesic, neurophysiological and perceptual responses to low‐load blood flow restriction exercise and high‐load resistance exercise, Norbury, R., Grant, I., Woodhead, A., Hughes, L., Tallent, J., Patterson, S. 1 May 2024, In: Experimental Physiology
Blood flow restriction: The acute effects of body tilting and reduced gravity analogues on limb occlusion pressure, Swain, P., Caplan, N., Hughes, L. 17 Aug 2024, In: Experimental Physiology
How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel: A Narrative Review, Gray, L., Ladlow, P., Coppack, R., Cassidy, R., Kelly, L., Lewis, S., Caplan, N., Barker-Davies, R., Bennett, A., Hughes, L. 6 Dec 2024, In: Sports Medicine - Open
Idiosyncratic bone responses to blood flow restriction exercise: new insights and future directions, Hughes, L., Centner, C. 1 Feb 2024, In: Journal of Applied Physiology
Impact of limb occlusion pressure assessment position on performance, cardiovascular, and perceptual responses in blood flow restricted low-load resistance exercise: A randomized crossover trial, Kamiş, O., Rolnick, N., de Queiros, V., Akçay, N., Keskin, K., Yıldız, K., Sofuoğlu, C., Werner, T., Hughes, L. 10 Nov 2024, In: Journal of Sports Sciences
It's time to regulate - The importance of accurate surgical-grade tourniquet autoregulation in blood flow restriction exercise applications, Hughes, L., Swain, P., Lai, T., McEwen, J. 1 May 2024, In: Physical Therapy in Sport
New insights into the impact of bed rest on lumbopelvic muscles: A computer-vision model approach to measure fat fraction changes, Wesselink, E., Hides, J., Elliott, J., Hoggarth, M., Weber II, K., Salomoni, S., Tran, V., Lindsay, K., Hughes, L., Weber, T., Scott, J., Hodges, P., Caplan, N., De Martino, E. 29 Nov 2024, In: Journal of Applied Physiology
No sex differences in oxygen uptake or extraction kinetics in the moderate or heavy exercise intensity domains, Solleiro Pons, M., Bernert, L., Hume, E., Hughes, L., Williams, Z., Burnley, M., Ansdell, P. 1 Mar 2024, In: Journal of Applied Physiology
The Discrepancy Between External and Internal Load/Intensity during Blood Flow Restriction Exercise: Understanding Blood Flow Restriction Pressure as Modulating Factor, Bielitzki, R., Behrens, M., Behrendt, T., Franz, A., Centner, C., Hughes, L., Patterson, S., Owens, J., Behringer, M., Schega, L. 4 Sep 2024, In: Sports Medicine - Open
Why blood flow restriction cuff features are an important methodological consideration- a short commentary on “cerebral cortex activation and functional connectivity during low-load resistance training with blood flow restriction: an fNIRS study”, Rolnick, N., Clarkson, M., Hughes, L., Korakakis, V., De Queiros, V., Patterson, S., Buckner, S., Werner, T., Nascimento, D., Stray-Gundersen, S., Kamiş, O., Thoelen, M., Kimbrell, K., Jacobs, E. 4 Dec 2024, In: Frontiers in Physiology

PGR Supervision

Bradley Barbour Start Date: 01/10/2024
Luke Gray Optimising the Therapeutic Effects of Blood Flow Restriction Exercise within UK Defence Rehabilitation Start Date: 01/10/2023

Qualifications

Philosophy PhD July 30 2019

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